The effects of fever on hormone ghrelins, immunoglobulins, and heat shock protein 70 expression after swine flu vaccinations
Identifieur interne : 001E04 ( Main/Exploration ); précédent : 001E03; suivant : 001E05The effects of fever on hormone ghrelins, immunoglobulins, and heat shock protein 70 expression after swine flu vaccinations
Auteurs : Suleyman Aydin [Turquie] ; Tumer Guven [Turquie] ; Brahim Sahin [Turquie] ; Aziz Aksoy [Turquie] ; Yalç N Kendir [Turquie] ; Mustafa N. Lhan [Turquie] ; Cihan Citil [Turquie] ; Zekiye Catak [Turquie] ; Cemal Ustun [Turquie]Source :
- Endocrine [ 1355-008X ] ; 2012-10-01.
English descriptors
Abstract
Abstract: For analyzing the changes in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence of fever associated with the it. The study included 11 subjects having developed a fever, and 13 subjects not having a fever, and 20 control subjects. Immunoglobulins were measured by nephelometry, and HSP70 and ghrelins by appropriate ELISA tests. The level of ghrelin was reduced, while the level of HSP70 was significantly increased in subjects who developed fevers. When temperatures were normalized, both levels were found similar to the control group. These results indicate that the increase in serum immunoglobulins levels associated with vaccinations, along with, elevations in HSP70 and reduced ghrelin levels associated with fever, may be the important parameters in the clinical evaluation and follow-up of treatments with vaccines.
Url:
DOI: 10.1007/s12020-012-9664-5
Affiliations:
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The study included 11 subjects having developed a fever, and 13 subjects not having a fever, and 20 control subjects. Immunoglobulins were measured by nephelometry, and HSP70 and ghrelins by appropriate ELISA tests. The level of ghrelin was reduced, while the level of HSP70 was significantly increased in subjects who developed fevers. When temperatures were normalized, both levels were found similar to the control group. These results indicate that the increase in serum immunoglobulins levels associated with vaccinations, along with, elevations in HSP70 and reduced ghrelin levels associated with fever, may be the important parameters in the clinical evaluation and follow-up of treatments with vaccines.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Aydin, Suleyman" sort="Aydin, Suleyman" uniqKey="Aydin S" first="Suleyman" last="Aydin">Suleyman Aydin</name></noRegion><name sortKey=" Lhan, Mustafa N" sort=" Lhan, Mustafa N" uniqKey=" Lhan M" first="Mustafa N." last=" Lhan">Mustafa N. Lhan</name><name sortKey="Aksoy, Aziz" sort="Aksoy, Aziz" uniqKey="Aksoy A" first="Aziz" last="Aksoy">Aziz Aksoy</name><name sortKey="Aksoy, Aziz" sort="Aksoy, Aziz" uniqKey="Aksoy A" first="Aziz" last="Aksoy">Aziz Aksoy</name><name sortKey="Aydin, Suleyman" sort="Aydin, Suleyman" uniqKey="Aydin S" first="Suleyman" last="Aydin">Suleyman Aydin</name><name sortKey="Catak, Zekiye" sort="Catak, Zekiye" uniqKey="Catak Z" first="Zekiye" last="Catak">Zekiye Catak</name><name sortKey="Citil, Cihan" sort="Citil, Cihan" uniqKey="Citil C" first="Cihan" last="Citil">Cihan Citil</name><name sortKey="Guven, Tumer" sort="Guven, Tumer" uniqKey="Guven T" first="Tumer" last="Guven">Tumer Guven</name><name sortKey="Kendir, Yalc N" sort="Kendir, Yalc N" uniqKey="Kendir Y" first="Yalç N" last="Kendir">Yalç N Kendir</name><name sortKey="Sahin, Brahim" sort="Sahin, Brahim" uniqKey="Sahin " first=" Brahim" last="Sahin"> Brahim Sahin</name><name sortKey="Sahin, Brahim" sort="Sahin, Brahim" uniqKey="Sahin " first=" Brahim" last="Sahin"> Brahim Sahin</name><name sortKey="Ustun, Cemal" sort="Ustun, Cemal" uniqKey="Ustun C" first="Cemal" last="Ustun">Cemal Ustun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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